Expression of glycoprotein non-metastatic melanoma protein B in cutaneous malignant and benign lesions： a tissue microarray study

• Published in: Chinese medical journal Vol. 125; no. 18; pp. 3279 - 3282
• Main Authors: Zhao, Yan, Qiao, Zheng-guo, Shan, Shi-jun, Sun, Qing-miao, Zhang, Jian-zhong
• Format: Journal Article
• Language: English
• Published: China Department of Dermatology, Peking University People's Hospital, Beijing 100044, China%Department of Central Laboratory , Peking University People's Hospital, Beijing 100044, China%Department of Dermatology, Tianjin Medical University General Hospital, Tianjin 300052, China 20.09.2012
• Subjects: Adolescent; Adult; Aged; Carcinoma, Basal Cell - metabolism; Carcinoma, Squamous Cell - metabolism; Female; Humans; Immunohistochemistry; Male; Melanoma - metabolism; Membrane Glycoproteins - metabolism; Middle Aged; Skin - metabolism; Skin - pathology; Skin Diseases - metabolism; Skin Neoplasms - metabolism; Tissue Array Analysis - methods; Young Adult; 免疫组化检测; 恶性黑色素瘤; 病变; 皮肤病; 糖蛋白; 组织芯片; 转移性; 鳞状细胞癌; tissue microarray; skin tumor; glycoprotein non-metastatic melanoma protein B
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2012.18.015

Background Glycoprotein non-metastatic melanoma protein B （GPNMB） plays an important role in the pathogenesis of inflammatory and malignant diseases. We investigated the expression of GPNMB in benign and malignant skin diseases. Methods Tissue microarray was performed in the skin tissues of 102 cases including malignant melanoma （MM）, squamous cell carcinoma （SCC）, basal cell carcinoma （BCC）, and benign dermatosis. The expression of GPNMB in the tissues was detected by immunohistochemistry. Twenty cases of normal skin and adjacent neoplastic normal skin tissues were selected as controls. Results GPNMB was positively stained in skin malignancies （38/50, 76%）, which was significantly higher than that in the control and the benign skin tissues （P=0.001 and 〈0.001 respectively）. GPNMB was positively stained in MM （13/15, 87%） and SCC （16/20, 80%） （P 〈0.001）. Significant higher expression of GPNMB was observed in patients aged 〉65 years than those less than 65 years （n=11 and n=9 respectively, P=0.027）. No significant difference of the expression rates was observed between normal control and BCC; however, stronger intensity was detected in the latter. Negative or weak expression was observed in the controls. Conclusion Over-expression of GPNMB correlated strongly and might play an important role in the pathogenesis of MM and SCC.