The release of histamine from rat mast cells by chymotrypsin

The release of histamine from rat peritoneal mast cells induced by alpha-chymotrypsin and that induced by antigen have characteristics in common. The kinetics of histamine release initiated by the two agents are similar. Both alpha-chymotrypsin and antigen release histamine in the absence of extrace...

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Bibliographic Details
Published inInternational archives of allergy and applied immunology Vol. 70; no. 1; p. 83
Main Authors Nials, A T, Vardey, C J, Skidmore, I F
Format Journal Article
LanguageEnglish
Published Switzerland 1983
Subjects
Animals
Antigens - pharmacology
Cell Survival
Chymotrypsin - pharmacology
Cromolyn Sodium - pharmacology
Histamine Release - drug effects
Mast Cells - metabolism
Rats
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Summary:The release of histamine from rat peritoneal mast cells induced by alpha-chymotrypsin and that induced by antigen have characteristics in common. The kinetics of histamine release initiated by the two agents are similar. Both alpha-chymotrypsin and antigen release histamine in the absence of extracellular calcium, phosphatidyl serine enhances the release, and disodium cromoglycate inhibits both reactions. In contrast, extracellular alpha-chymotrypsin does not induce histamine release from cells isolated from fragments of human lung, human basophils, histamine-containing cells lavaged from the bronchial lumen of the rhesus monkey, fragments of human lung and fragments of guinea pig lung.
ISSN:0020-5915
DOI:10.1159/000233278