Studies of inhibition of the plasmin-plasminogen fibrinolytic enzyme system in patients with myocardial infarction

The plasma of twenty-one patients with acute myocardial infarction who had not received heparin and the plasma of thirty-seven patients with acute myocardial infarction who had received heparin were tested for antiplasmin activity. The plasma of twenty-nine control subjects was similarly tested. Pla...

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Bibliographic Details
Published inThe American journal of cardiology Vol. 5; no. 5; pp. 666 - 673
Main Authors Sandberg, Herschel, Tsitouris, George, deLeon, Antonio C., Bellet, Samuel
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.1960
Subjects
Blood Coagulation
Fibrinolysin
Humans
Myocardial Infarction - blood
Old Medline
Plasminogen
FIBRINOLYSIN
BLOOD COAGULATION
MYOCARDIAL INFARCT/blood
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Summary:The plasma of twenty-one patients with acute myocardial infarction who had not received heparin and the plasma of thirty-seven patients with acute myocardial infarction who had received heparin were tested for antiplasmin activity. The plasma of twenty-nine control subjects was similarly tested. Plasma fibrinogen levels were determined in these groups. Antiplasmin activity was increased significantly over the control group in both groups of patients with myocardialin farction. Plasma fibrinogen levels paralleled the increased antiplasmin activity. A brief review of the literature on fibrinolysin inhibitors and their possible relation to the pathogenesis of atherosclerosis is discussed. The increased antiplasmin activity in patients with myocardial infarction appears to confirm the importance of impaired fibrinolytic processes in atherosclerosis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0002-9149
1879-1913
DOI:10.1016/0002-9149(60)90134-X