Plasma glycoproteins in diseases of the hemopoietic system

• Published in: Clinica chimica acta Vol. 11; no. 2; pp. 113 - 117
• Main Authors: Chyrek-Borowska, S., Deptulski, T.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.1965
• Subjects: Blood Protein Disorders; Blood Protein Electrophoresis; Blood Proteins; Glycoproteins; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Neuraminic Acids; Old Medline; Plasma; HODGKIN'S DISEASE; NEURAMINIC ACIDS; BLOOD PROTEINS; BLOOD PROTEIN ELECTROPHORESIS; GLYCOPROTEINS; BLOOD PROTEIN DISORDERS; LEUKEMIA, LYMPHOCYTIC
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/0009-8981(65)90203-2

A total of 60 patients with various diseases of the hemopoietic system were investigated. The levels of plasma proteins, neuraminic acid, protein-bound hexose, seromucoid and neuraminic acid in seromucoid were determined. Parallelism in the behaviour of constituents of the carbohydrate complex was observed. The highest values of neuraminic acid, hexose, and seromucoid were found in the acute phase of lymphogranulomatosis and myelosis. In lymphatic leukemia, on the other hand, the level of neuraminic acid was much lower. The level of neuraminic acid in plasma seromucoid was found to be especially high in Hodgkin's disease. It may be supposed that the shift in the level of seromucoid is due to the increase in the amount of the carbohydrate component rather than of the protein component. It was found that when the patients were treated with steroids or cytostatic drugs, the level of plasma glycoproteins decreased. We consider that assays of neuraminic acid and seromucoid are more reliable than those of hexose for detecting changes in glycoproteins.