Influence of the antigenicity of target cells on the antibody-mediated cytotoxicity of nonsensitized lymphocytes

The effect of various antigen concentrations on the surface of target cells on IgG-mediated cytotoxicity of nonsensitized lymphocytes was studied using benzylpenicilloyl (BPO)-coated chicken erythrocytes as target cells, anti-BPO rabbit IgG, and human lymphocytes as effector cells. The number of ant...

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Bibliographic Details
Published inCellular immunology Vol. 17; no. 2; pp. 440 - 446
Main Authors Wiedermann, G., Denk, H., Stemberger, H., Eckerstorfer, R., Tappeiner, G.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.06.1975
Subjects
Animals
Antigens
Binding Sites, Antibody
Chickens - immunology
Chromium Radioisotopes
Cytotoxicity Tests, Immunologic
Erythrocytes - immunology
Fluorescent Antibody Technique
Hemolytic Plaque Technique
Humans
Immune Sera
Immunoglobulin Fc Fragments
Lymphocytes - immunology
Penicillin G - immunology
Rabbits - immunology
Tannins
Time Factors
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Summary:The effect of various antigen concentrations on the surface of target cells on IgG-mediated cytotoxicity of nonsensitized lymphocytes was studied using benzylpenicilloyl (BPO)-coated chicken erythrocytes as target cells, anti-BPO rabbit IgG, and human lymphocytes as effector cells. The number of antigenic sites on the target cell was calculated. The results indicate that a critical density of antigenic sites and consequently a close association of the Fc-parts of the antibody molecules is necessary for the induction of cytotoxicity.
ISSN:0008-8749
1090-2163
DOI:10.1016/S0008-8749(75)80048-7