Homocysteine in small-for-gestational age and appropriate-for-gestational age preterm neonates from mothers receiving folic acid supplementation

• Published in: Clinical chemistry and laboratory medicine Vol. 48; no. 8; pp. 1157 - 1161
• Main Authors: Gomes, Thushari S., Lindner, Ulrike, Tennekoon, Kamani H., Karandagoda, Wimal, Gortner, Ludwig, Obeid, Rima
• Format: Journal Article
• Language: English
• Published: Berlin Walter de Gruyter 01.08.2010; De Gruyter
• Subjects: Adult; appropriate-for-gestational age; Biological and medical sciences; Birth Weight; Diseases of mother, fetus and pregnancy; Female; Fetal Blood - chemistry; Fetal Growth Retardation - etiology; Folic Acid - analysis; Folic Acid - therapeutic use; Folic Acid Deficiency - drug therapy; folic acid supplementation; General aspects; Gestational Age; Gynecology. Andrology. Obstetrics; homocysteine; Homocysteine - blood; Humans; Infant, Newborn; Infant, Small for Gestational Age - blood; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; methylenetetrahydrofolate reductase polymorphism; Mothers; Predictive Value of Tests; Pregnancy; Pregnancy. Fetus. Placenta; Premature Birth; small-for-gestational age; Vitamin B 12 - analysis; Premature; Methylenetetrahydrofolate reductase (NADPH); Intrauterine growth retardation; Genetic variability; Pregnancy disorders; Vitamin; folic acid supplementation; Folic acid; Gestational age; Fetal diseases; Homocystein; Mother; Clinical biology; Developmental stage; Supplementation; Human; homocysteine; Thiol; small-for-gestational age; Nutrition; Enzyme; Low birth weight; ); Genotype; Recommendation; methylenetetrahydrofolate reductase polymorphism; 5,10-Methylenetetrahydrofolate reductase (FADH; Sulfur containing aminoacid; Pregnancy; Medicine; Newborn diseases; Newborn; Prematurity; appropriate-for-gestational age; Oxidoreductases; Polymorphism
• ISSN: 1434-6621; 1437-4331
• DOI: 10.1515/CCLM.2010.235

Background: Prematurity and small-for-gestational age (SGA) neonates are at risk for postnatal complications. Concentrations of total homocysteine (tHcy) might be related to neonatal outcome. We hypothesized that concentrations of tHcy are not related to growth restriction in neonates from mothers receiving 5 mg/day folic acid. We studied a total of 133 preterm neonates from normotensive mothers; SGA (n=96) and appropriate-for-gestational age (AGA, n=37). Methods: Concentrations of tHcy, folate and vitamin B12 were measured in venous umbilical cord plasma. Results: AGA preterm neonates had higher mean birth weight (BW) compared to SGA preterms (2472 g vs. 2007 g; p<0.001) of comparable mean gestational age (GA) (35.1 vs. 35.7 weeks; p=0.059). Concentrations of tHcy (4.86 vs. 4.95 μmol/L), folate (63.3 vs. 55.7 nmol/L), and vitamin B12 (409 vs. 394 pmol/L) were not significantly different between the groups. GA was a strong positive predictor, BW was a significant negative predictor of cord plasma folate. Vitamin B12 concentration was a significant negative predictor of cord tHcy. Conclusions: Concentrations of tHcy did not differ between SGA and AGA preterm neonates born to mothers supplemented with folic acid. This finding argues against a causal role for folate deficiency or increased tHcy in growth restriction. Clin Chem Lab Med 2010;48:1157–61.