New synthetic methodology leading to a series of novel heterocyclic α-aminophosphonates: a very attractive expansion of Kabachnik–Fields reaction

• Published in: Tetrahedron Vol. 68; no. 15; pp. 3156 - 3159
• Main Authors: Qu, Zhibo, Chen, Xiaolan, Yuan, Jinwei, Bai, Yunliang, Chen, Tong, Qu, Lingbo, Wang, Fujun, Li, Xu, Zhao, Yufen
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.04.2012; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Exact sciences and technology; Heterocyclic compounds; Heterocyclic α-Aminophosphonates; Intramolecular cyclization; Kabachnik–Fields reaction; Kinetics and mechanisms; Mechanism; Methodology; Noncondensed benzenic compounds; One-pot; Organic chemistry; Organometalloidal and organometallic compounds; P derivatives; Physical Sciences; Preparations and properties; Reactivity and mechanisms; Science & Technology; Synthesis (chemistry); Tetrahedrons; Intramolecular cyclization; One-pot; Heterocyclic α-Aminophosphonates; Mechanism; Kabachnik–Fields reaction; MOIETY; Heterocyclic alpha-Aminophosphonates; Kabachnik-Fields reaction; DERIVATIVES; Intramolecular reaction; One pot reaction; Kabachnik―Fields reaction; Multicomponent reaction; Organic phosphonate; Oxygen phosphorus heterocycle; Phosphorus Organic compounds; Cyclization; Acetophenone derivatives; Reaction mechanism; Benzenic compound; Chemical synthesis; Heterocyclic compound; Benzaldehyde derivatives
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/j.tet.2012.02.059

A convenient one-pot three-component approach leading to synthesis of a series of novel heterocyclic α-aminophosphonates starting either from 2-hydroxyacetophenones or 2-hydroxybenzaldehyes was developed. [Display omitted]