Interaction between sedative premedicants and ketamine in man in isolated perfused rat livers

Premedication with diazepam, hydroxyzine or secobarbital significantly increased ketamine-induced sleep time (137 +/- 3.5 min, 135 +/- 9.2 min, 128 +/- 4.7 min) over that of unpremedicated controls (98.5 +/- 4.4 min) in man. The corresponding mean plasma half-lives (t1/2) of ketamine were longer in...

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Bibliographic Details
Published inAnesthesiology (Philadelphia) Vol. 43; no. 3; pp. 307 - 312
Main Authors Lo, J N, Cumming, J F
Format Journal Article
LanguageEnglish
Published United States 01.09.1975
Subjects
Anesthetics - metabolism
Anesthetics - pharmacology
Animals
Atropine - administration & dosage
Biotransformation
Child
Child, Preschool
Diazepam - administration & dosage
Drug Interactions
Half-Life
Humans
Injections, Intramuscular
Ketamine - blood
Ketamine - metabolism
Ketamine - pharmacology
Liver - drug effects
Liver - metabolism
Preanesthetic Medication
Rats
Secobarbital - administration & dosage
Sleep - drug effects
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Summary:Premedication with diazepam, hydroxyzine or secobarbital significantly increased ketamine-induced sleep time (137 +/- 3.5 min, 135 +/- 9.2 min, 128 +/- 4.7 min) over that of unpremedicated controls (98.5 +/- 4.4 min) in man. The corresponding mean plasma half-lives (t1/2) of ketamine were longer in patients premedicated with diazepam or seconbarbital (57.8 +/- 4.9 min, 46 +/- 3.2 min) than in controls (36 +/- 1.8 min). Ketamine t1/2 in the perfusate of isolated, perfused rat livers was prolonged 30 to 50 per cent by addition of diazepam, secobarbital, or hydroxyzine. The data suggest that these commonly used premedicants decrease the rate of ketamine metabolism.
ISSN:0003-3022
DOI:10.1097/00000542-197509000-00007