Influence of the immunomodulating compound BM 12.531 (azimexone) on radioresistance and granulopoietic colony forming units in mice

BM 12.531 (azimexone) increases the survival of mice exposed to 650 rad. Levamisole, isoprenosine or aristolochia acid have no effects in this system. After administration of 25 mg/kg azimexone to C57 Bl/6-mice a statistically significant increase in CFUc was found. Maybe this increase in CFUc can e...

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Bibliographic Details
Published inExperimental pathology (1981) Vol. 20; no. 2; p. 105
Main Authors Gassel, W D, Laukel, H, Braun, R, Werner, T, Bicker, U
Format Journal Article
LanguageEnglish
Published Germany 1981
Subjects
Adjuvants, Immunologic - pharmacology
Animals
Aziridines - pharmacology
Azirines - pharmacology
Female
Granulocytes - drug effects
Hematopoietic Stem Cells - drug effects
Male
Mice
Mice, Inbred Strains
Radiation-Protective Agents - pharmacology
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Summary:BM 12.531 (azimexone) increases the survival of mice exposed to 650 rad. Levamisole, isoprenosine or aristolochia acid have no effects in this system. After administration of 25 mg/kg azimexone to C57 Bl/6-mice a statistically significant increase in CFUc was found. Maybe this increase in CFUc can explain the radioprotective effect of azimexone.
ISSN:0232-1513
DOI:10.1016/S0232-1513(81)80017-5