High resolution nmr and x-ray crystallography data of caudicifolin from Euphorbia acaulis

• Published in: Phytochemistry (Oxford) Vol. 25; no. 6; pp. 1411 - 1413
• Main Authors: Satti, N.K., Suri, O.P., Dhar, K.L., Atal, C.K., Kawasaki, Toshio, Miyahara, Kazumoto, Kawano, Shigeako
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 22.05.1986; Elsevier
• Subjects: 13C NMR; Analytical, structural and metabolic biochemistry; Biological and medical sciences; caudicifolin; Euphorbia; Euphorbia acaulis; Euphorbiaceae; Fundamental and applied biological sciences. Psychology; lactones; nuclear magnetic resonance spectroscopy; Other biological molecules; rhizomes; Terpenes, steroids. Hormones; X-ray crystallography; X-ray diffraction; X-ray crystallography; Euphorbiaceae; 13C NMR; Euphorbia acaulis; caudicifolin; Vegetals; Molecular structure; Dicotyledones; Angiospermae; Diterpene; Spermatophyta
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(00)81299-6

A diterpene lactone was isolated from the cold petrol (60−80°) extract of rhizomes of Euphorbia acaulis, a plant material used by a tribe of central India for curing various inflammatory disorder. The diterpene, which was observed to be identical to caudicifolin on the basis of its physical constants, was subjected to high resolution NMR spectroscopy and X-ray crystallography examination. This paper reports the salient features of the 2D 1H NMR, 13C NMR and X-ray crystallography data of the compound. 13C NMR assignments were made by the use of proton noise decoupling, SFORD, APT and automatic spectral editing techniques. 1H NMR assignments were made with the aid of a COSY experiment for long range couplings and NOE correlated 2D-experiments. The 1H and 13C NMR spectral assignments have been further corroborated by H/C correlation experimental results.