Integration of Hollow Microneedle Arrays with Jellyfish-Shaped Electrochemical Sensor for the Detection of Biomarkers in Interstitial Fluid

This study integrates hollow microneedle arrays (HMNA) with a novel jellyfish-shaped electrochemical sensor for the detection of key biomarkers, including uric acid (UA), glucose, and pH, in artificial interstitial fluid. The jellyfish-shaped sensor displayed linear responses in detecting UA and glu...

Full description

Saved in:
Bibliographic Details
Published inSensors (Basel, Switzerland) Vol. 24; no. 12; p. 3729
Main Authors Luo, Fangfang, Li, Zhanhong, Shi, Yiping, Sun, Wen, Wang, Yuwei, Sun, Jianchao, Fan, Zheyuan, Chang, Yanyi, Wang, Zifeng, Han, Yutong, Zhu, Zhigang, Marty, Jean-Louis
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.06.2024
MDPI
Subjects
3-D printers
Animals
Biomarkers
Biomarkers - analysis
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Blood vessels
Carbon
Diabetes
Disease
Electrochemical Techniques - instrumentation
Electrochemical Techniques - methods
Electrodes
Extracellular Fluid - chemistry
Glucose
Glucose - analysis
Humans
Hydrogen-Ion Concentration
interstitial fluid
Medical diagnosis
microneedle array
Needles
Organic chemicals
Personal health
Sensors
Stencils
Uric acid
Uric Acid - analysis
Work stations
United States > US
China
pH
interstitial fluid
microneedle array
glucose
uric acid
Online AccessGet full text

Cover

More Information
Summary:This study integrates hollow microneedle arrays (HMNA) with a novel jellyfish-shaped electrochemical sensor for the detection of key biomarkers, including uric acid (UA), glucose, and pH, in artificial interstitial fluid. The jellyfish-shaped sensor displayed linear responses in detecting UA and glucose via differential pulse voltammetry (DPV) and chronoamperometry, respectively. Notably, the open circuit potential (OCP) of the system showed a linear variation with pH changes, validating its pH-sensing capability. The sensor system demonstrates exceptional electrochemical responsiveness within the physiological concentration ranges of these biomarkers in simulated epidermis sensing applications. The detection linear ranges of UA, glucose, and pH were 0~0.8 mM, 0~7 mM, and 4.0~8.0, respectively. These findings highlight the potential of the HMNA-integrated jellyfish-shaped sensors in real-world epidermal applications for comprehensive disease diagnosis and health monitoring.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1424-8220
1424-8220
DOI:10.3390/s24123729