Very late return of spermatogenesis after chlorambucil therapy: case reports

Two men were treated for a nephrotic syndrome with high-dose chlorambucil therapy; 6.5 and 14 years later, respectively, both were azoospermic with high plasmatic FSH values. Both patients showed active spermatogenesis, 15 and 19 years after the end of the treatment. This suggests that a return of s...

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Bibliographic Details
Published inFertility and sterility Vol. 58; no. 4; pp. 845 - 846
Main Authors Marmor, Dominique, Grob-Menendez, Françoise, Duyck, Francis, Delafontaine, Didier
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.1992
Subjects
Adult
alkylating agents
azoospermia
chlorambucil
Chlorambucil - adverse effects
Chlorambucil - pharmacology
Chlorambucil - therapeutic use
Humans
immunosuppressive therapy
infertility
Male
nephrotic syndrome
Oligospermia - chemically induced
Spermatogenesis - drug effects
Sterility
Time Factors
immunosuppressive therapy
alkylating agents
azoospermia
infertility
chlorambucil
Sterility
nephrotic syndrome
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Summary:Two men were treated for a nephrotic syndrome with high-dose chlorambucil therapy; 6.5 and 14 years later, respectively, both were azoospermic with high plasmatic FSH values. Both patients showed active spermatogenesis, 15 and 19 years after the end of the treatment. This suggests that a return of spermatogenesis can occur even after very high cumulative doses of chlorambucil (between 3,000 and 6,500 mg) and after a very long time.
ISSN:0015-0282
1556-5653
DOI:10.1016/S0015-0282(16)55342-4