Effect of oat bran on plasma cholesterol and bile acid excretion in nine subjects with ileostomies

• Published in: The American journal of clinical nutrition Vol. 56; no. 1; pp. 99 - 105
• Main Authors: Zhang, JX, Hallmans, G, Andersson, H, Bosaeus, I, Aman, P, Tidehag, P, Stenling, R, Lundin, E, Dahlgren, S
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.07.1992; American Society for Clinical Nutrition
• Subjects: ABSORCION DE SUBSTANCIAS NUTRITIVAS; ABSORPTION DE SUBSTANCES NUTRITIVES; ACIDE BILIAIRE; ACIDOS BILIARES; administration & dosage; Adult; ADULTE; ADULTOS; adults; Aged; AGUAS RESIDUALES; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anticholesteremic Agents; Anticholesteremic Agents - administration & dosage; AVENAS; AVOINE; bile acids; Bile Acids and Salts; Bile Acids and Salts - metabolism; Biological and medical sciences; blood; blood lipids; blood plasma; Bread; chemical composition; Chenodeoxycholic Acid; Chenodeoxycholic Acid - metabolism; CHOLESTEROL; Cholesterol - blood; Cholic Acid; Cholic Acids; Cholic Acids - metabolism; COLESTEROL; COMPLEMENTATION; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; DIETA; dietary fiber; Dietary Fiber - administration & dosage; dietary supplements; EAU USEE; Edible Grain; effluents; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition; ENERGIA; ENERGIE; energy intake; Energy Metabolism; ENRIQUECIMIENTO DE LOS ALIMENTOS; ESTEROLES; EXCRECION; EXCRETION; experimental diets; EXPERIMENTATION; EXPERIMENTOS; Female; FIBRA DE LA DIETA; FIBRE ALIMENTAIRE; Humans; Ileostomy; Intensive care medicine; INTESTIN; INTESTINOS; LIPEMIA; LIPEMIE; Lipid Metabolism; Lipids; Lipids - blood; Male; Medical sciences; metabolism; METABOLISME DES LIPIDES; METABOLISMO DE LIPIDOS; Middle Aged; Nitrogen; Nitrogen - metabolism; nutrient intake; Oat bran; OPERACIONES QUIRURGICAS; OPERATION CHIRURGICALE; plasma lipids; PLASMA SANGUIN; PLASMA SANGUINEO; Random Allocation; REGIME ALIMENTAIRE; SALVADO; SON; STEROL; sterol excretion; sterols; sterol excretion; plasma lipids; humans; Oat bran; ileostomy; Human; Oat; Bile acid; Lipids; Supplemented diet; Dietary fiber; Metabolism; Cholesterol; Enteral administration; Feeding; Blood plasma
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/56.1.99

A higher excretion of dry matter, fat, nitrogen, energy, and total bile acids in ileal effluents; a lower plasma low-density-lipoprotein (LDL) and total cholesterols (12.1% and 9.0% lower respectively); but no change in plasma high-density-lipoprotein (HDL) cholesterol or apolipoproteins A-I and B were observed in nine subjects with ileostomies when they consumed an oat-bran, bread-based, high-fiber diet (HFD) as compared with a wheat-flour, bread-based, low-fiber diet (LFD) for 3 wk with a crossover design. Of the nine subjects only the subjects with a low daily excretion of bile acids had an elevated excretion of total bile acids during the HFD compared with the LFD. Total cholesterol, LDL cholesterol, and apolipoprotein B in plasma also decreased by 11.3%, 15.3%, and 10.7%, respectively, after consumption of the HFD for 3 wk.