Chromatin Variants Reveal the Genetic Determinants of Oncogenesis in Breast Cancer

Breast cancer presents as multiple distinct disease entities. Each tumor harbors diverse cell populations defining a phenotypic heterogeneity that impinges on our ability to treat patients. To date, efforts mainly focused on genetic variants to find drivers of inter- and intratumor phenotypic hetero...

Full description

Saved in:
Bibliographic Details
Published inCold Spring Harbor perspectives in medicine Vol. 12; no. 10; p. a041322
Main Authors Bahl, Shalini, Carroll, Jason S, Lupien, Mathieu
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.10.2022
Subjects
Carcinogenesis
Cell Transformation, Neoplastic
Chromatin - genetics
Genetic Heterogeneity
Humans
Neoplasms
Precision Medicine
Online AccessGet full text

Cover

More Information
Summary:Breast cancer presents as multiple distinct disease entities. Each tumor harbors diverse cell populations defining a phenotypic heterogeneity that impinges on our ability to treat patients. To date, efforts mainly focused on genetic variants to find drivers of inter- and intratumor phenotypic heterogeneity. However, these efforts have failed to fully capture the genetic basis of breast cancer. Through recent technological and analytical approaches, the genetic basis of phenotypes can now be decoded by characterizing chromatin variants. These variants correspond to polymorphisms in chromatin states at DNA sequences that serve a distinct role across cell populations. Here, we review the function and causes of chromatin variants as they relate to breast cancer inter- and intratumor heterogeneity and how they can guide the development of treatment alternatives to fulfill the goal of precision cancer medicine.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Editors: Jane E. Visvader, Jeffrey M. Rosen, and Samuel Aparicio
Additional Perspectives on Breast Cancer: From Fundamental Biology to Therapeutic Strategies available at www.cshperspectives.org
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a041322