Limb regeneration in salamanders: the plethodontid tale

Salamanders are the only vertebrates that can regenerate limbs as adults. This makes them ideal models to investigate the cellular and molecular mechanisms of tissue regeneration. and have long served as primary salamander models of limb regeneration, and the recent sequencing of the axolotl genome...

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Bibliographic Details
Published inThe International journal of developmental biology Vol. 65; no. 4-5-6; pp. 313 - 321
Main Authors Arenas-Gómez, Claudia M, Delgado, Jean-Paul
Format Journal Article
LanguageEnglish
Published Spain University of the Basque Country Press 2021
Subjects
Ambystoma mexicanum - genetics
Ambystoma mexicanum - growth & development
Amphibians
Animals
Extremities - growth & development
Genomes
Molecular modelling
Next-generation sequencing
Regeneration
Reptiles & amphibians
Tissue engineering
Urodela - genetics
Urodela - growth & development
Vertebrates
Wound Healing
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Summary:Salamanders are the only vertebrates that can regenerate limbs as adults. This makes them ideal models to investigate the cellular and molecular mechanisms of tissue regeneration. and have long served as primary salamander models of limb regeneration, and the recent sequencing of the axolotl genome now provides a blueprint to mine regeneration insights from other salamander species. In particular, there is a need to study South American plethodontid salamanders that present different patterns of limb development and regeneration. A broader sampling of species using next-generation sequencing approaches is needed to reveal shared and unique mechanisms of regeneration, and more generally, the evolutionary history of salamander limb regeneration.
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ISSN:0214-6282
1696-3547
DOI:10.1387/ijdb.200228jd