The effects of the somatostatin analogue SMS 201-995 on carbohydrate homeostasis of insulin-dependent diabetics as assessed by the artificial endocrine pancreas

• Published in: Diabetes research and clinical practice Vol. 5; no. 2; pp. 91 - 98
• Main Authors: Hadjidakis, Dimitrios J., Halvatsiotis, Panayotis G., Ioannou, Yannakis J., Mavrokefalos, Paris J., Raptis, Sotos A.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 13.07.1988
• Subjects: Adult; Artificial endocrine pancreas; Blood Glucose - metabolism; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Female; Glucagon - blood; Glucagon - metabolism; Growth Hormone - blood; Growth Hormone - metabolism; Humans; Hypoglycemic Agents - therapeutic use; Insulin Infusion Systems; Insulin-dependent diabetes; Kinetics; Male; Octreotide; Somatostatin - analogs & derivatives; Somatostatin - therapeutic use; Somatostatin analogues; Artificial endocrine pancreas; Somatostatin analogues; Insulin-dependent diabetes
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/S0168-8227(88)80047-0

On the basis of the inhibitory actions of the somatostatin analogue SMS 201-995 on growth hormone (GH) and glucagon (IRG) secretion we investigated its effects on carbohydrate metabolism of insulin-dependent diabetics. Six patients with no residual insulin secretion were connected to the artificial endocrine pancreas (AEP) and after the establishment of a steady state overnight they were injected either normal saline or 50 μg of SMS 201-995 s.c., t.i.d., or 100 μg of the same compound b.i.d. Insulin requirements were assessed by the AEP and compared during the 24 h and after the main meals. The inhibition of GH and IRG secretion was evaluated as well. 50 μg of SMS analogue t.i.d. induced a significant reduction of insulin requirement (mean ± SEM) while no significant difference was observed between control and 100 μg s.c., b.i.d., nor between 50 μg and 100 μg. The curve of glucose fluctuations was smoother after 50 μg than after 100 μg and control. Postprandial IRG secretion was inhibited by both regimens of SMS after lunch and dinner. GH secretion was significantly inhibited after all meals during the days of analogue administration. SMS 201-995 analogue appears to have a remarkable antidiabetic activity as shown by the sparing of administered amount of insulin, suppression of counter-insulin hormones and smoothing of blood glucose curve. It may constitute a safe and effective adjunctive measure in the management of insulin-dependent diabetics.