Translational synthetic chemistry

Providing chemical matter to modulate newly identified biological targets—as well as pre-existing but chemically intractable ones—remains a challenge in the discovery of therapeutics. Here, we discuss opportunities for synthetic chemists to make a direct impact in addressing targets that are conside...

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Bibliographic Details
Published inNature chemical biology Vol. 9; no. 4; pp. 210 - 213
Main Authors Kesavan, Sarathy, Marcaurelle, Lisa A
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.04.2013
Nature Publishing Group
Subjects
631/1647/666/2261
631/92/349
631/92/436
631/92/95
Biochemical Engineering
Biochemistry
Biological Products - chemistry
Biological Products - isolation & purification
Biological Products - pharmacology
Bioorganic Chemistry
Catalysis
Cell Biology
Cell Survival - drug effects
Chemical synthesis
Chemistry
Chemistry/Food Science
commentary
Drug Design
Drug Discovery
Humans
Molecular Targeted Therapy
Peptides - chemical synthesis
Peptides - pharmacology
Small Molecule Libraries - chemistry
Small Molecule Libraries - isolation & purification
Small Molecule Libraries - pharmacology
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Summary:Providing chemical matter to modulate newly identified biological targets—as well as pre-existing but chemically intractable ones—remains a challenge in the discovery of therapeutics. Here, we discuss opportunities for synthetic chemists to make a direct impact in addressing targets that are considered 'undruggable'.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1552-4450
1552-4469
DOI:10.1038/nchembio.1207