Liposome-integrated hydrogel hybrids: Promising platforms for cancer therapy and tissue regeneration

Drug delivery platforms have gracefully emerged as an indispensable component of novel cancer chemotherapy, bestowing targeted drug distribution, elevating therapeutic effects, and reducing the burden of unwanted side effects. In this context, hybrid delivery systems artfully harnessing the virtues...

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Bibliographic Details
Published inJournal of controlled release Vol. 368; pp. 703 - 727
Main Authors Sanati, Mehdi, Amin Yavari, Saber
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2024
Subjects
Cancer
Drug Delivery Systems - methods
Hybrid platforms
Hydrogels
Hydrogels - chemistry
Liposomes
Liposomes - chemistry
Neoplasms - drug therapy
Tissue regeneration
Hybrid platforms
Liposomes
Hydrogels
Tissue regeneration
Cancer
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Summary:Drug delivery platforms have gracefully emerged as an indispensable component of novel cancer chemotherapy, bestowing targeted drug distribution, elevating therapeutic effects, and reducing the burden of unwanted side effects. In this context, hybrid delivery systems artfully harnessing the virtues of liposomes and hydrogels bring remarkable benefits, especially for localized cancer therapy, including intensified stability, excellent amenability to hydrophobic and hydrophilic medications, controlled liberation behavior, and appropriate mucoadhesion to mucopenetration shift. Moreover, three-dimensional biocompatible liposome-integrated hydrogel networks have attracted unprecedented interest in tissue regeneration, given their tunable architecture and physicochemical properties, as well as enhanced mechanical support. This review elucidates and presents cutting-edge developments in recruiting liposome-integrated hydrogel systems for cancer treatment and tissue regeneration. [Display omitted] •Liposome-integrated hydrogel (Li-Gel) systems effectively mitigate the limitations inherent in individual platforms.•Li-Gel systems exhibit favorable biocompatibility, tunability, and physicochemical, structural, and mechanical properties.•Li-Gel systems could be therapeutically targeted or engineered as tailored drug delivery platforms.•Li-Gel systems bring notable benefits for localized cancer therapy and tissue regeneration.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2024.03.008