Noncommunicable disease among adults with cerebral palsy: A matched cohort study

• Published in: Neurology Vol. 93; no. 14; p. e1385
• Main Authors: Ryan, Jennifer M, Peterson, Mark D, Matthews, Anthony, Ryan, Nicola, Smith, Kimberley J, O'Connell, Neil E, Liverani, Silvia, Anokye, Nana, Victor, Christina, Allen, Elizabeth
• Format: Journal Article
• Language: English
• Published: United States 01.10.2019
• Subjects: Adult; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - therapy; Cerebral Palsy - epidemiology; Cerebral Palsy - therapy; Cohort Studies; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - therapy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Noncommunicable Diseases - epidemiology; Noncommunicable Diseases - therapy; Respiration Disorders - epidemiology; Respiration Disorders - therapy; Risk Factors
• ISSN: 1526-632X
• DOI: 10.1212/WNL.0000000000008199

To compare the incidence of noncommunicable diseases between adults with and without cerebral palsy (CP). A cohort study was conducted using primary care data from the Clinical Practice Research Datalink. Cox models, stratified by matched set and adjusted for potential confounders, were fitted to compare the risk of any noncommunicable disease, cancer, cardiovascular disease, type 2 diabetes mellitus, and respiratory disease between adults with and without CP. The analysis included 1,705 adults with CP and 5,115 age-, sex-, and general practice-matched adults without CP. There was evidence from adjusted analyses that adults with CP had 75% increased risk of developing any noncommunicable disease compared to adults without CP (hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.58-1.94). Specifically, they had increased risk of cardiovascular disease (HR 1.76, 95% CI 1.48-2.11) and respiratory disease (HR 2.61, 95% CI 2.14-3.19). There was no evidence of increased risk of cancer or type 2 diabetes mellitus. Adults with CP had increased risk of noncommunicable disease, specifically cardiovascular and respiratory disease. These findings highlight the need for clinical vigilance regarding identification of noncommunicable disease in people with CP and further research into the etiology and management of noncommunicable disease in this population.