Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor δ chain

• Published in: The Journal of experimental medicine Vol. 169; no. 5; pp. 1557 - 1564
• Main Authors: WRIGHT, A, LEE, J. E, LINK, M. P, SMITH, S. D, CARROLL, W, LEVY, R, CLAYBERGER, C, KRENSKY, A. M
• Format: Journal Article
• Language: English
• Published: New York, NY Rockefeller University Press 01.05.1989; The Rockefeller University Press
• Subjects: Adolescent; Antibodies, Monoclonal; Antigens, Differentiation - analysis; Antigens, Differentiation - immunology; Antigens, Differentiation, T-Lymphocyte - analysis; Antigens, Differentiation, T-Lymphocyte - immunology; Antigens, Neoplasm - immunology; B-Lymphocytes - immunology; Biological and medical sciences; Burkitt Lymphoma - immunology; CD3 Complex; CD8 Antigens; Cell Line, Transformed; Child; Cytotoxic reactions (adcc reaction, cell-mediated lympholysis, complement-dependent cytotoxicity and others); Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Herpesvirus 4, Human; HLA-DR Antigens - analysis; HLA-DR1 Antigen; Humans; Immunobiology; Immunoglobulin Idiotypes - immunology; Immunological reactions in vitro; Lymphocyte Function-Associated Antigen-1; Male; Receptors, Antigen, T-Cell - analysis; Receptors, Antigen, T-Cell - immunology; T-Lymphocytes, Cytotoxic - immunology; Tumor Cells, Cultured; Human; Cell cloning; Cell culture; Cytolysis; Immunoglobulins; T cell receptor; Antigenic determinant; Cytotoxicity; B-Lymphocyte; Monoclonal antibody; Antigen; Phenotype; Specificity; Cell line; T»-Lymphocyte; Tumor cell; Recognition; Idiotype
• ISSN: 0022-1007; 1540-9538
• DOI: 10.1084/jem.169.5.1557

CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+,CD4-,CD8- and express the delta chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy.