Preparation and characterization of 58S bioactive glass based scaffold with Kaempferol‐containing Zein coating for bone tissue engineering

• Published in: Journal of biomedical materials research. Part B, Applied biomaterials Vol. 109; no. 9; pp. 1259 - 1270
• Main Authors: Ranjbar, Faezeh Esmaeili, Foroutan, Farzad, Hajian, Mahdieh, Ai, Jafar, Farsinejad, Alireza, Ebrahimi‐Barough, Somaye, Dehghan, Mohammad Mehdi, Azami, Mahmoud
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.09.2021; Wiley Subscription Services, Inc
• Subjects: 58S bioactive glass; Biodegradation; Bioglass; Biological activity; Biomedical materials; Bone and Bones - chemistry; Bone growth; bone tissue engineering; Cell Adhesion; Cell Line; Cell Proliferation; Ceramics - chemistry; Coated Materials, Biocompatible - chemistry; Coatings; Cytology; Drug Carriers - chemistry; Drug Liberation; foam casting; Glass - chemistry; Humans; Hydrophobic and Hydrophilic Interactions; Kaempferol; Kaempferols - chemistry; Kaempferols - pharmacology; Materials research; Materials science; Mechanical Phenomena; Mechanical properties; Morphology; Porosity; Regeneration; Regeneration (physiology); Scaffolds; Surface Properties; Tissue engineering; Tissue Scaffolds - chemistry; Zein; Zein - chemistry; foam casting; Zein; Kaempferol; bone tissue engineering; 58S bioactive glass
• ISSN: 1552-4973; 1552-4981
• DOI: 10.1002/jbm.b.34786

The aim of this study was to prepare a porous scaffold out of 58S bioactive glass as the bare and coated with Zein to improve mechanical properties and acting as a carrier for Kaempferol controlled delivery. Porosity and morphology, mechanical properties, drug release behavior, bioactivity, cell attachment, and biodegradation of the scaffolds were evaluated accordingly. Obtained results indicated that the scaffolds coated by (7wt/v %) Zein solution, showed the highest mechanical strength (3.06 ± 0.4 MPa) and desirable porous morphology. These scaffolds could support bioactivity, cell attachment, and provide sustained drug release in the safe range of Kaempferol concentration confirmed via 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide analysis. Overall, this study showed that the Zein‐coated scaffold possesses superior properties rather than bare scaffold, and the scaffolds coated with 7wt/v % Zein solution could be considered as appropriate scaffolds for bone regeneration.