Clinical efficacy of paiteling in the treatment of condyloma acuminatum infected with different subtypes of HPV

• Published in: Dermatologic therapy Vol. 32; no. 5; pp. e13065 - n/a
• Main Authors: Hu, Yanqing, Lu, Yan, Qi, Xinyu, Chen, Xuyang, Liu, Kangxing, Zhou, Xianyi, Yang, Yemei, Mao, Zuhao, Wu, Zhong, Hu, Yongxuan
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.09.2019
• Subjects: Administration, Topical; Adult; Biopsy, Needle; China; clinical efficacy; Cohort Studies; condyloma acuminatum; Condylomata Acuminata - drug therapy; Condylomata Acuminata - virology; Drugs, Chinese Herbal - administration & dosage; Female; HPV; Humans; Immunohistochemistry; Male; Medicine, Chinese Traditional; Middle Aged; paiteling; Papillomavirus Infections - drug therapy; Papillomavirus Infections - physiopathology; Papillomavirus Infections - virology; Prognosis; Retrospective Studies; Severity of Illness Index; Treatment Outcome; China; clinical efficacy; paiteling; condyloma acuminatum; HPV
• ISSN: 1396-0296; 1529-8019
• DOI: 10.1111/dth.13065

Condyloma acuminatum (CA) is a type of mucosal benign hyperplasia skin disease that is caused by human papillomavirus (HPV) infection, which mainly occurs in the genitalia and anus. The aim of the present study was to explore the clinical efficacy underlying the traditional Chinese medicine paiteling in the treatment of CA via the detection of HPV. One hundred CA patients were enrolled in the current study and were externally treated with paiteling for 5 weeks. HPV subtypes were examined both before the treatment and at 6 months after the treatment. After the external paiteling therapy, 92 cases were cured, and the apparent efficiency was 92.0% (92/100), while 8 cases exhibited recurrence. Before the external paiteling therapy, the numbers of cases of low‐risk, high‐risk, and mixed types of HPV were 40, 35, and 25, respectively. At 6 months after treatment, the numbers of negative cases of low‐risk, high‐risk, and mixed types of HPV were 38, 32, and 20, respectively. The results demonstrated that external paiteling treatment has a good curative effect on the treatment of CA.