Survival and Endoscopic/Clinical Features of Patients with Colorectal Cancer Resected by Cold Snare Polypectomy: The Importance of Chronic Kidney Disease

• Published in: Kurume medical journal Vol. 71; no. 1.2; pp. MS7112002 - 9
• Main Authors: NAGATA, TSUTOMU, SAKAI, MIWA, MUKASA, MICHITA, TANAKA, HIROSHI, MINAMI, SHINPEI, CHO, TOMONORI, NAKANE, TOMOYUKI, OHUCHI, AKIHIRO, FUKUNAGA, SHUHEI, AKIBA, JUN, OKABE, YOSHINOBU, KAWAGUCHI, TAKUMI
• Format: Journal Article
• Language: English
• Published: Japan Kurume University School of Medicine 27.09.2024
• Subjects: Adult; Aged; Aged, 80 and over; chronic kidney disease; cold polypectomy; colon cancer; colon polyp; Colonic Polyps - complications; Colonic Polyps - surgery; Colonoscopy - methods; Colorectal Neoplasms - complications; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - mortality; Colorectal Neoplasms - surgery; Decision Trees; Female; Glomerular Filtration Rate; histological diagnosis; Humans; magnifying endoscopy; Male; Middle Aged; pre-diabetes; Prognosis; Renal Insufficiency, Chronic - complications; Risk Factors; chronic kidney disease; colon polyp; pre-diabetes; histological diagnosis; colon cancer; magnifying endoscopy; cold polypectomy; prognosis
• ISSN: 0023-5679; 1881-2090; 1881-2090
• DOI: 10.2739/kurumemedj.MS7112002

Background and Aims: Colorectal polyps resected by cold snare polypectomy (CSP) are rarely diagnosed as colorectal cancer (CRC). We aimed to investigate the prevalence, clinical features, and prognosis of patients with CRC resected by CSP. Subjects: Patients with colorectal polyps treated with CSP between 2018 and 2022 were enrolled and regularly followed up (median observation period: 30.6 months). Logistic regression analysis and decision tree analysis were employed to investigate the clinical features of the patients. Results: A total of 5,064 colorectal polyps from 2,530 patients were resected by CSP. Of these, 0.24% were diagnosed as CRC; however, no patients died due to CRC. eGFR was an independent risk factor for the presence of CRC (unit 10, OR 0.716, 95%CI 0.525-0.973, P=0.0323) and its optimal cut-off value was 59.9 mL/min/1.73 m2. The decision-tree analysis revealed that 2.03% of patients with creatinine ≥ 1.0 mg/dL had CRC. Conclusion: CRC was diagnosed in 0.24% of the polyps; however, no patients died due to CRC. eGFR <60 mL/min/1.73 m2 and creatinine >1.0 mg/dL were associated with CRC. Thus, colorectal polyps should be carefully examined in patients with chronic kidney disease.