Graphene as multifunctional delivery platform in cancer therapy

The biomedical applications of graphene‐based nanomaterials including drug and gene delivery have grown rapidly in the past few years. This is due to its high surface area that results in high cargo loading capacity. It is demonstrated that graphene can improve drug efficacy without increasing the d...

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Bibliographic Details
Published inJournal of biomedical materials research. Part A Vol. 105; no. 8; pp. 2355 - 2367
Main Authors Nejabat, Mojgan, Charbgoo, Fahimeh, Ramezani, Mohammad
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.08.2017
Subjects
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Bearing strength
Biocompatibility
Biomedical materials
Cancer
Cancer therapies
Cargo capacity
Cytotoxicity
Drug Carriers - chemistry
Drug Carriers - toxicity
drug delivery
Drug delivery systems
Drug Delivery Systems - adverse effects
Drug Delivery Systems - methods
gene delivery
Gene transfer
Gene Transfer Techniques - adverse effects
Genetic Therapy - methods
Graphene
graphene oxide
Graphite - chemistry
Graphite - toxicity
Humans
Nanomaterials
Nanomedicine - methods
Nanostructures - chemistry
Nanostructures - toxicity
Nanotechnology
Neoplasms - therapy
Reviews
targeting
Therapy
gene delivery
graphene oxide
targeting
drug delivery
graphene
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Summary:The biomedical applications of graphene‐based nanomaterials including drug and gene delivery have grown rapidly in the past few years. This is due to its high surface area that results in high cargo loading capacity. It is demonstrated that graphene can improve drug efficacy without increasing the dose of the chemotherapeutic agent in cancer treatment. Considering these valuable benefits of graphene, this review focused on the newest advancements in drug and gene delivery systems using graphene and unveiling advantages and disadvantages of different graphene‐based materials in introducing an effective cargo delivery system for cancer therapy. Different approaches for reducing cytotoxic impacts of graphene oxide and production of biocompatible delivery platform were also reviewed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2355–2367, 2017.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.36080