Selective inhibitory effect of benzaldehyde on the growth of Simian virus 40-transformed cells

Normal and Simian virus 40-transformed cells were treated with benzaldehyde which has been found in figs as a potent carcinostatic element. Benzaldehyde notably inhibited the growth of transformed cells when cells were cultivated in the presence of 25 μg/ml of benzaldehyde. No significant effect was...

Full description

Saved in:
Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 87; no. 4; pp. 1024 - 1030
Main Authors Miyakawa, Tokichi, Zundel, Jean-Luc, Sakaguchi, Kenji
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 27.04.1979
Subjects
Animals
Benzaldehydes - metabolism
Benzaldehydes - pharmacology
Cell Division - drug effects
Cell Line
Cell Transformation, Neoplastic - drug effects
Kinetics
Membrane Proteins - metabolism
Protein Binding
Rats
Simian virus 40
Online AccessGet full text

Cover

More Information
Summary:Normal and Simian virus 40-transformed cells were treated with benzaldehyde which has been found in figs as a potent carcinostatic element. Benzaldehyde notably inhibited the growth of transformed cells when cells were cultivated in the presence of 25 μg/ml of benzaldehyde. No significant effect was observed at this concentration on the growth of normal cells. In the presence of 50 μg/ml of benzaldehyde the growth of transformed cells was completely inhibited. The growth inhibition by 50 μg/ml of benzaldehyde was reversible and cells resumed growth after removal of the chemical from the media. A labeling experiment of cells with [ 14C]-benzaldehyde indicated that the reaction of benzaldehyde with cellular proteins was limited mainly to exposed membrane proteins.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(79)80010-8