Synaptic vesicle pools

Communication between cells reaches its highest degree of specialization at chemical synapses. Some synapses talk in a 'whisper'; others 'shout'. The 'louder' the synapse, the more synaptic vesicles are needed to maintain effective transmission, ranging from a few hundr...

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Bibliographic Details
Published inNature reviews. Neuroscience Vol. 6; no. 1; pp. 57 - 69
Main Authors Betz, William J, Rizzoli, Silvio O
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.01.2005
Subjects
Animals
Anura
Carassius auratus
Drosophila
Freshwater
Humans
Insects
Physiology
Recycling
Synapses - metabolism
Synapses - secretion
Synaptic Transmission - physiology
Synaptic Vesicles - metabolism
Synaptic Vesicles - secretion
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Summary:Communication between cells reaches its highest degree of specialization at chemical synapses. Some synapses talk in a 'whisper'; others 'shout'. The 'louder' the synapse, the more synaptic vesicles are needed to maintain effective transmission, ranging from a few hundred (whisperers) to nearly a million (shouters). These vesicles reside in different 'pools', which have been given a bewildering array of names. In this review, we focus on five tissue preparations in which synaptic vesicle pools have been identified and thoroughly characterized. We argue that, in each preparation, each vesicle can be assigned to one of three distinct pools.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1471-003X
1471-0048
1471-0048
1469-3178
DOI:10.1038/nrn1583