Relationship Between Olfactory Disturbance After Acute Ischemic Stroke and Latent Thalamic Hypoperfusion

Odor detection, recognition, and identification were assessed in 19 acute ischemic stroke patients who had no magnetic resonance imaging-detectable thalamic lesions but in whom technetium-99m ethyl cysteinate dimer single photon emission tomography revealed thalamic hypoperfusion. Although these pat...

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Published inChemical senses Vol. 45; no. 2; pp. 111 - 118
Main Authors Okamoto, Kazuhiro, Shiga, Hideaki, Nakamura, Hisako, Matsui, Makoto, Miwa, Takaki
Format Journal Article
LanguageEnglish
Published England 25.03.2020
Subjects
Aged
Female
Humans
Ischemic Stroke - diagnostic imaging
Ischemic Stroke - physiopathology
Male
Odorants - analysis
Olfaction Disorders - diagnostic imaging
Olfaction Disorders - physiopathology
Thalamic Diseases - diagnostic imaging
Thalamic Diseases - physiopathology
Tomography, Emission-Computed, Single-Photon
cerebral perfusion
olfaction
brain injury
human brain
thalamus
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Summary:Odor detection, recognition, and identification were assessed in 19 acute ischemic stroke patients who had no magnetic resonance imaging-detectable thalamic lesions but in whom technetium-99m ethyl cysteinate dimer single photon emission tomography revealed thalamic hypoperfusion. Although these patients were unaware of reduced olfactory function, they exhibited significantly lower scores in tests for odor identification and recognition threshold as compared with 9 ischemic stroke controls that had normal thalamic hypoperfusion. However, absolute odor detection thresholds were similar in the 2 groups. These results demonstrate the usefulness of cerebral perfusion scintigraphy in assessing sensory loss after ischemic stroke and provide further evidence for the role of the thalamus in olfaction.
Bibliography:ObjectType-Article-1
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ISSN:0379-864X
1464-3553
DOI:10.1093/chemse/bjz077