Urinary excretion of N-nitrosodiethanolamine administered orally to rats

N-Nitrosodiethanolamine (NDE1A) was administered by gavage to male rats in single doses of 1000, 500 and 100 mg/kg body wt. More than 70% of a given dose was excreted unchanged in the urine, essentially within the first 24 h after exposure. This high excretion rate might explain the relatively low c...

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Bibliographic Details
Published inCancer letters Vol. 4; no. 4; pp. 207 - 209
Main Authors Preussmann, Rudolf, Wurtele, Gerd, Eisenbrand, Gerhard, Spiegelhalder, Bertold
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.01.1978
Subjects
Administration, Oral
Animals
Diethylnitrosamine - administration & dosage
Diethylnitrosamine - analogs & derivatives
Diethylnitrosamine - urine
Male
Nitrosamines - urine
Rats
Time Factors
gas chromatography/mass spectrometry
N-nitrosodiethanolamine
NDE1A
GC/MS
HPLC
high-pressure liquid chromatography
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Summary:N-Nitrosodiethanolamine (NDE1A) was administered by gavage to male rats in single doses of 1000, 500 and 100 mg/kg body wt. More than 70% of a given dose was excreted unchanged in the urine, essentially within the first 24 h after exposure. This high excretion rate might explain the relatively low carcinogenic potential of NDE1A, and also offers a possible method of monitoring exposure to this compound under occupational and/or environmental conditions.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(78)94512-3