Assessment of steroidogenesis and steroidogenic enzyme functions

• Published in: The Journal of steroid biochemistry and molecular biology Vol. 137; pp. 176 - 182
• Main Author: Luu-The, Van
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2013
• Subjects: Androgen biosynthesis; Backdoor pathway; Cancer cells; CYP17A1; Dihydrotestosterone; Estradiol; Humans; Intracrine; Oestrogen biosynthesis; Steroid 17-alpha-Hydroxylase - metabolism; Steroidogenesis; Steroids - biosynthesis; Testosterone; DHEA; PREG; UGT; 3β-HSD; Intracrine; Androgen biosynthesis; 3α-HSD; 17β-HSD; E1; E2; CholS; 17-OH-PREG; ADT; STS; Cancer cells; CYP11A; CYP19; Oestrogen biosynthesis; 3β-diol; Backdoor pathway; 5-diol; 17β-HSDn; 4-dione; 3α-diol; ER; SARM; AR; epi-ADT; Steroidogenesis; ADT-G; E1S; 17-OH-PROG; Estradiol; CYP17A1; DHT; Dihydrotestosterone; DHEAS; SULT1E1; T; CYP21A; 3β-diol-G; 3α-diol-G; SULT1A3; 3β-HSDn; 5α-redn; epi-ADTS; 5α-red; Testosterone; PROG; androsterone; 5α-androstane-3β,17β-diol; 5α-androstane-3β17β-diol glucuronide; epi-androsterone sulfate; estrone; UDT-glucuronosyl transferase; 5α-androstane-3α,17β-diol glucuronide; androgen receptor; estrogen sulfotransferase type 1; type n 3β-hydroxysteroid dehydrogenase; 17β-hydroxysteroid dehydrogenase; 5α-reductase; type n 5α-reductase; 17-hydroxyprogesterone; steroid sulfotransferase; dehydroepiandrosterone; 5-androstene-3β,17β-diol; 3α-hydroxysteroid dehydrogenase; 17-hydroxypregnenolone; selective androgen receptor modulator; type n 17β- hydroxysteroid dehydrogenase; P450 side chain cleavage (P450scc); 17α-hydroxylase/17–20 lyase (P450c17); phenol sulfotransferase type 3; dehydroepiandroserone sulfate; progesterone; P450 21-hydroxylase (P450c21); cholesterol sulfate; 3β-hydroxysteroid dehydrogenase; 4-androstenedione; epi-androsterone; aromatase; estrogen receptor; estrone sulfate; androsterone glucuronide; pregnenolone; 5α-androstane-3α,17β-diol

•Clarification of steroidogenesis in endocrine glands and steroidogenesis in peripheral intracrine tissues.•Pathways of dihydrotestosterone and estradiol biosynthesis that do not require testosterone as intermediate.•Importance of kinetic constants in establishing steroidogenic pathways.•The role of...