The role of nucleocytoplasmic transport in mechanotransduction

Cells integrate mechanical and biochemical signals via a process called mechanotransduction to generate essential gene expression patterns in space and time. This is vital for cell migration and proliferation as well as tissue morphogenesis and remodeling. While the force-sensing and force-transduci...

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Bibliographic Details
Published inExperimental cell research Vol. 377; no. 1-2; pp. 86 - 93
Main Authors Kassianidou, Elena, Kalita, Joanna, Lim, Roderick Y.H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.04.2019
Subjects
Active Transport, Cell Nucleus
Animals
Cell Nucleus - metabolism
Cytoplasm - metabolism
Humans
Mechanotransduction, Cellular
Phosphoproteins - metabolism
Transcription Factors - metabolism
NPC
cNLS
ncNLS
NCT
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Summary:Cells integrate mechanical and biochemical signals via a process called mechanotransduction to generate essential gene expression patterns in space and time. This is vital for cell migration and proliferation as well as tissue morphogenesis and remodeling. While the force-sensing and force-transducing mechanisms are generally known, it remains unclear how mechanoresponsive transcription factors (TFs) are selectively translocated into the nucleus upon force activation. Such TFs include Yes-Associated Protein (YAP), Myocardin Related Transcription Factors (MRTFs), Hypoxia Induced Factors (HIFs) and others. Here, we discuss how the nucleocytoplasmic transport machinery intersects with mechanoresponsive TFs to facilitate their selective transport through nuclear pore complexes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0014-4827
1090-2422
DOI:10.1016/j.yexcr.2019.02.009