Flavonoids from Ziziphus jujuba Mill var. spinosa

• Published in: Tetrahedron Vol. 56; no. 45; pp. 8915 - 8920
• Main Authors: Cheng, Gong, Bai, Yanjing, Zhao, Yuying, Tao, Jing, Liu, Yi, Tu, Guangzhong, Ma, Libin, Liao, Ning, Xu, Xiaojie
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 03.11.2000; Elsevier
• Subjects: 6‴-feruloylisospinosin; Chemistry; Chemistry, Organic; conformers; isospinosin; Physical Sciences; Science & Technology; sedative activity; spinosin; Ziziphus jujuba Mill var. spinosa, flavonoid, flavone-C-glycoside; Ziziphus jujuba Mill var. spinosa, flavonoid, flavone-C-glycoside; conformers; spinosin; 6‴-feruloylisospinosin; isospinosin; sedative activity; Ziziphus jujuba Mill var. spinosa; flavone-C-glycoside; 6 '''-feruloylisospinosin; flavonoid
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/S0040-4020(00)00842-5

Eight flavonoid compounds were isolated from the seeds of Ziziphus jujuba Mill var. Spinosa. On the basis of chemical and spectral analyses their structures were elucidated as swertish ( 1), puerarin ( 2), 6‴-feruloylspinosin ( 3), apigenin-6- C-β- d-glucopyranoside ( 4), spinosin ( 5), 6‴-feruloylisospinosin ( 6), isospinosin ( 7), and isovitexin-2″- O-β- d-glucopyranoside ( 8). Flavonoids 6 and 7 are novel compounds. Rotamers exist for compounds 1, 3 and 5, which are reported for the first time. Compounds 2, 4 and 8 were isolated from this plant for the first time. Spinosin and swertish possess significant sedative activity.