SIRT6 serves as a polyhedron in glycolytic metabolism and ageing-related diseases

• Published in: Experimental gerontology Vol. 162; p. 111765
• Main Authors: Yuan, Zhixiao, Zeng, Yutian, Tian, Yao, Wang, Shuai, Hong, Binyan, Yang, Mingyao
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.06.2022
• Subjects: Ageing; Aging; Cancer; Glycolysis; Humans; Metabolism; Neoplasms - metabolism; Neurodegenerative Diseases; SIRT6; Sirtuins - metabolism; SIRT6; Neurodegenerative diseases; Metabolism; Ageing; Cancer
• ISSN: 0531-5565; 1873-6815
• DOI: 10.1016/j.exger.2022.111765

Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide (NAD+)-dependent enzyme. It is a novel member of the sirtuin family that has been shown to have an important role in various molecular pathways in glycolysis, cancer, and neurodegenerative responses. Recently, SIRT6 has emerged as a prominent research issue because its biochemical activity and regulation are possibly associated with human metabolism and disease. In this review, we summarized the connection between SIRT6 and glycolytic metabolism; discussed recent developments in the involvement of SIRT6 in a variety of life-threatening illnesses, including cancer, neurodegenerative diseases and cardiovascular disease; and explored possible treatment approaches for those diseases with SIRT6. This review provides insights into the role of SIRT6 in disease. •The role of SIRT6 in the metabolic pathways of glucose regulation, gluconeogenesis and glycolysis•The regulation of SIRT6 in breast, liver, lung and skin cancers•The function of SIRT6 in heart disease and ageing-related Alzheimer's diseases•The potential therapeutic target of SIRT6