Fluid restriction during running increases GI permeability

The purpose of this study was to determine gastrointestinal (GI) permeability during prolonged treadmill running (60 min at 70 % V.O2max) with and without fluid intake (3 ml/kg body mass/10 min). Twenty runners (11 males, 9 females; age = 22 +/- 3 (SD) yrs; mean V.O2max = 55.7 +/- 5.0 ml/kg/min) com...

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Bibliographic Details
Published inInternational journal of sports medicine Vol. 29; no. 3; p. 194
Main Authors Lambert, G P, Lang, J, Bull, A, Pfeifer, P C, Eckerson, J, Moore, G, Lanspa, S, O'Brien, J
Format Journal Article
LanguageEnglish
Published Germany 01.03.2008
Subjects
Adult
Double-Blind Method
Duodenum - metabolism
Female
Gastrointestinal Agents - pharmacokinetics
Gastrointestinal Agents - urine
Glucose Solution, Hypertonic - pharmacokinetics
Humans
Intestinal Absorption - physiology
Intestine, Small - metabolism
Lactulose - pharmacokinetics
Lactulose - urine
Male
Permeability
Rest - physiology
Rhamnose - pharmacokinetics
Rhamnose - urine
Running - physiology
Sucrose - pharmacokinetics
Sucrose - urine
Sweetening Agents - pharmacokinetics
Water Deprivation
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Summary:The purpose of this study was to determine gastrointestinal (GI) permeability during prolonged treadmill running (60 min at 70 % V.O2max) with and without fluid intake (3 ml/kg body mass/10 min). Twenty runners (11 males, 9 females; age = 22 +/- 3 (SD) yrs; mean V.O2max = 55.7 +/- 5.0 ml/kg/min) completed four experiments: 1) rest, 2) running with no fluid (NF), 3) running with ingestion of a 4 % glucose solution (GLU), and 4) running with ingestion of a water placebo (PLA). To determine GI permeability, subjects also drank a solution containing 5 g sucrose (S), 5 g lactulose (L), and 2 g rhamnose (R) immediately prior to each trial. Gastroduodenal permeability was determined by urinary S excretion, while small intestinal permeability was determined by the L/R excretion ratio. Percent body mass loss (i.e., dehydration) was negligible during rest, GLU and PLA, while NF resulted in a 1.5 % loss of body mass (p < 0.05). Gastroduodenal and intestinal permeability were significantly (p < 0.008) increased in NF compared to rest. There were no other differences in GI permeability. These results indicate that fluid restriction during 1 h of steady-state running increases GI permeability above resting levels.
ISSN:0172-4622
DOI:10.1055/s-2007-965163