Intramolecular hydrogen bonding of nucleobases

The intramolecular hydrogen bonding of a series of linked uracil, thymine and adenine derivatives is described. The nucleoside bases have been linked by semi-flexible spacers and the chemical shifts and Δ δNH/Δ T values for the nucleoside NH protons confirm the strong intramolecular hydrogen bonding...

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Bibliographic Details
Published inTetrahedron letters Vol. 43; no. 17; pp. 3157 - 3160
Main Authors Crisp, Geoffrey T., Jiang, Yu-Lin
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 22.04.2002
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
BASE-PAIR
DESIGN
MODEL
DNA
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Summary:The intramolecular hydrogen bonding of a series of linked uracil, thymine and adenine derivatives is described. The nucleoside bases have been linked by semi-flexible spacers and the chemical shifts and Δ δNH/Δ T values for the nucleoside NH protons confirm the strong intramolecular hydrogen bonding motif. The intramolecular hydrogen bonding of a series of linked uracil, thymine and adenine derivatives is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)00483-5