NBPF1 independently determine the risk stratification and prognosis of patients with neuroblastoma

Neuroblastoma is the most frequent extracranial malignant solid tumor in children, and the 5 year OS of high risk neuroblastoma patients was less than 15%. This study aimed to identify biomarkers for risk stratification and prognosis prediction in neuroblastoma.149 low risk samples, 108 intermediate...

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Bibliographic Details
Published inGenomics (San Diego, Calif.) Vol. 112; no. 6; pp. 3951 - 3957
Main Authors Zhang, Jing, Zhao, Yuanyuan, Wang, Jianhua, Sneh, Tal, Yu, Qianqian, Zhou, Xiao, Gong, Chen
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2020
Subjects
Bioinformatics
NBPF1
Neuroblastoma
Prognosis
Risk stratification
Prognosis
Neuroblastoma
NBPF1
Bioinformatics
Risk stratification
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Summary:Neuroblastoma is the most frequent extracranial malignant solid tumor in children, and the 5 year OS of high risk neuroblastoma patients was less than 15%. This study aimed to identify biomarkers for risk stratification and prognosis prediction in neuroblastoma.149 low risk samples, 108 intermediate risk samples and 619 high risk samples were included in our study, and NBPF1 gene was found to be significantly correlated with risk levels and OS. Significant negative correlations between NBPF1 and the expression of MYCN and AKT1S1, and positive correlations between NBPF1 and KIF1B expression were found, but only NBPF1 was an independent biomarker based on the construct of PPI for MYCN, NBPF1, KIF1B and AKT1S1 by STRING enrichment.
Bibliography:ObjectType-Article-1
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ISSN:0888-7543
1089-8646
DOI:10.1016/j.ygeno.2020.06.038