Isolation of drug residues from tissues by solid phase dispersion

A new method based on solid phase dispersion of tissue for the subsequent isolation of drugs is reported. By blending tissues with a polymeric phase bound to a solid support one obtains a semi-dry material which can be used as a column packing material from which one can isolate drugs in a stepwise...

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Bibliographic Details
Published inJournal of chromatography Vol. 475; p. 353
Main Authors Barker, S A, Long, A R, Short, C R
Format Journal Article
LanguageEnglish
Published Netherlands 1989
Subjects
Animals
Anti-Bacterial Agents - isolation & purification
Cattle
Chromatography, Gas
Chromatography, High Pressure Liquid
Drug Residues - isolation & purification
Lactams
Muscles - analysis
Spectrophotometry, Ultraviolet
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Summary:A new method based on solid phase dispersion of tissue for the subsequent isolation of drugs is reported. By blending tissues with a polymeric phase bound to a solid support one obtains a semi-dry material which can be used as a column packing material from which one can isolate drugs in a stepwise fashion based on the solubility characteristics of the drugs in this matrix. The applicability of this approach for multidrug residue extraction from a single sample is demonstrated for compounds representing the organophosphate, benzimidazole anthelmintic and beta-lactam antibiotic drug classes.
DOI:10.1016/S0021-9673(01)89689-8