θ-γ Cross-Frequency Transcranial Alternating Current Stimulation over the Trough Impairs Cognitive Control
Cognitive control is a mental process, which underlies adaptive goal-directed decisions. Previous studies have linked cognitive control to electrophysiological fluctuations in the θ band and θ-γ cross-frequency coupling (CFC) arising from the cingulate and frontal cortices. However, to date, the beh...
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Published in | eNeuro Vol. 7; no. 5; p. ENEURO.0126-20.2020 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Society for Neuroscience
01.09.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Cognitive control is a mental process, which underlies adaptive goal-directed decisions. Previous studies have linked cognitive control to electrophysiological fluctuations in the θ band and θ-γ cross-frequency coupling (CFC) arising from the cingulate and frontal cortices. However, to date, the behavioral consequences of different forms of θ-γ CFC remain elusive. Here, we studied the behavioral effects of the θ-γ CFC via transcranial alternating current stimulation (tACS) designed to stimulate the frontal and cingulate cortices in humans. Using a double-blind, randomized, repeated measures study design, 24 healthy participants were subjected to three active and one control CFC-tACS conditions. In the active conditions, 80-Hz γ tACS was coupled to 4-Hz θ tACS. Specifically, in two of the active conditions, short γ bursts were coupled to the delivered θ cycle to coincide with either its peaks or troughs. In the third active condition, the phase of a θ cycle modulated the amplitude of the γ oscillation. In the fourth, control protocol, 80-Hz tACS was continuously superimposed over the 4-Hz tACS, therefore lacking any phase specificity in the CFC. During the 20 min of stimulation, the participants performed a Go/NoGo monetary reward-based and punishment-based instrumental learning task. A Bayesian hierarchical logistic regression analysis revealed that relative to the control, the peak-coupled tACS had no effects on the behavioral performance, whereas the trough-coupled tACS and, to a lesser extent, amplitude-modulated tACS reduced performance in conflicting trials. Our results suggest that cognitive control depends on the phase specificity of the θ-γ CFC. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 eNeuro Authors report no conflict of interest. Z.T. and M.M. contributed equally to this work. This work was financially supported by the Deutsche Forschungsgemeinschaft Grant PA 419/15-1 (to W.P.). A.L. was supported by the International Max Planck Research School for Neurosciences. A.A. was supported by the State of Lower Saxony, Germany Grant 76251-12-7/19 (ZN 3456). Author contributions: Z.T. conceptualization; Z.T. and W.P. designed research; Z.T. and H.B. performed research; Z.T., M.M., and A.L. contributed analytic tools; M.M. and A.L. analyzed data; Z.T., M.M., A.L., H.B., A.A., and W.P. wrote the paper. |
ISSN: | 2373-2822 2373-2822 |
DOI: | 10.1523/ENEURO.0126-20.2020 |