Structure and functions of tumor necrosis factor-alpha converting enzyme

Tumor necrosis factor-alpha converting enzyme (TACE) is the first described and best characterized secretase. In this review the structure and the possible roles for TACE are summarized. The substrate specificity and the regulation of TACE activity as well as redundancy and possible cooperations of...

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Bibliographic Details
Published inActa biochimica polonica Vol. 50; no. 3; pp. 625 - 645
Main Authors Mezyk, Renata, Bzowska, Monika, Bereta, Joanna
Format Journal Article
LanguageEnglish
Published Poland 01.01.2003
Subjects
ADAM Proteins
ADAM17 Protein
Animals
Enzyme Activation - physiology
Metalloendopeptidases - genetics
Metalloendopeptidases - metabolism
Metalloproteases - genetics
Metalloproteases - metabolism
Mice
Mice, Knockout
Protein Structure, Secondary - genetics
Protein Structure, Secondary - physiology
Substrate Specificity - physiology
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Summary:Tumor necrosis factor-alpha converting enzyme (TACE) is the first described and best characterized secretase. In this review the structure and the possible roles for TACE are summarized. The substrate specificity and the regulation of TACE activity as well as redundancy and possible cooperations of distinct secretases are also discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0001-527X
1734-154X
DOI:10.18388/abp.2003_3656