Co-Sr doped carbonated hydroxyapatite: A biomaterial with enhanced mechanical and bioactivity properties

The present study is aimed at investigating the role of two biologically important cations, cobalt (Co2+) and strontium (Sr2+) doped into carbonated hydroxyapatite (CHA) crystal structure. Four different compositions of Co-Sr CHA powders were synthesized via nanoemulsion method at ambient temperatur...

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Bibliographic Details
Published inJournal of physics. Conference series Vol. 1082; no. 1; pp. 12076 - 12081
Main Authors Muhammad Syazwan, M.N., Ahmad-Fauzi, M.N., Yanny Marliana, B.I
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.08.2018
Subjects
Ambient temperature
Apatite
Biological activity
Biomedical materials
Carbonation
Cobalt
Composition
Crystal structure
Hydroxyapatite
In vitro methods and tests
Mechanical properties
Nanoemulsions
Physics
Sintering (powder metallurgy)
Synthesis
Tensile strength
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Summary:The present study is aimed at investigating the role of two biologically important cations, cobalt (Co2+) and strontium (Sr2+) doped into carbonated hydroxyapatite (CHA) crystal structure. Four different compositions of Co-Sr CHA powders were synthesized via nanoemulsion method at ambient temperature. Among the as-synthesized powders, Co-Sr CHA 1 (0.0082wt% Co, 0.0547wt% Sr) and Co-Sr CHA 2 (0.0085wt% Co, 0.0261wt% Sr) were chosen as the optimum compositions and used for fabrication of dense products. Sintering was then performed on the Co-Sr CHA compacted samples at 900°C in air, followed by cooled down in dry CO2 atmosphere at temperature of 200°C. Regardless of their compositions, the sintered samples remained as single phase B-type CHA. Co-Sr CHA 1 has the optimum mechanical properties where the relative density and diametral tensile strength (DTS) values obtained were 89.15% and 7.67 MPa, respectively. In vitro bioactivity test revealed that the formation of apatite layer were detected on the surface of all sintered samples after soaking in SBF solution for 7 days, with Co-Sr CHA 1 showing the fastest apatite formation as compared to CHA and Co-Sr CHA 2. Results obtained indicate that simultaneous doping of Co2+ and Sr2+ into CHA structure gives rise to improved mechanical strength as well as enhanced the bioactivity of the apatite.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1082/1/012076