Suspected Carboplatin Extravasation Reactions in Seven Dogs

• Published in: The Journal of the American Animal Hospital Association Vol. 54; no. 6; p. 360
• Main Authors: Miller, Kristina Bowles, Lejeune, Amandine, Regan, Rebecca, Szivek, Anna, Kow, Kevin
• Format: Journal Article
• Language: English
• Published: United States 01.11.2018
• ISSN: 0587-2871
• DOI: 10.5326/jaaha-ms-6773

Carboplatin is a platinum chemotherapeutic agent commonly used in veterinary oncology that is currently classified as an irritant to local tissues when extravasated. To the authors' knowledge, there are no reports of vesicant injuries associated with carboplatin administration reported in the veterinary literature. In this case series, seven dogs are described to have experienced injuries following a suspected carboplatin extravasation resembling vesicant injuries a median of 7 days after carboplatin administration (range 4-15 days). Wounds healed with a variety of treatments, including medical management and/or surgical debridement, a median of 25.5 days (range 7-49 days) after observation of the suspected extravasation injury. There were no obvious similarities involving carboplatin administration among patients to explain why these reactions occurred. Extravasation injury should be considered a possible local complication associated with carboplatin chemotherapy.