Lower Maternal Chronic Physiological Stress and Better Child Behavior at 18 Months: Follow-Up of a Cluster Randomized Trial of Neonatal Intensive Care Unit Family Integrated Care

• Published in: The Journal of pediatrics Vol. 243; pp. 107 - 115.e4
• Main Authors: Mclean, Mia A., Scoten, Olivia C., Yu, Wayne, Ye, Xiang Y., Petrie, Julie, Church, Paige T., Soraisham, Amuchou S., Mirea, Lucia S., Weinberg, Joanne, Synnes, Anne R., O'Brien, Karel, Grunau, Ruth E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2022
• Subjects: Carcinoma, Hepatocellular; Child; Child Behavior; cortisol; Dehydroepiandrosterone; Delivery of Health Care, Integrated; family-centered care; Female; Follow-Up Studies; Humans; Hydrocortisone; hypothalamic–pituitary–adrenal axis; Infant; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Liver Neoplasms; neonatal follow-up; prematurity; preterm; Prospective Studies; Stress, Physiological; Stress, Psychological - therapy; DHEA; prematurity; FICare; ACME; NCAST; preterm; ITSEA; neonatal follow-up; HCC; NICU; hypothalamic–pituitary–adrenal axis; cRCT; cortisol; HPA; family-centered care
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2021.12.055

To assess whether Family Integrated Care (FICare) in the neonatal intensive care unit improves maternal chronic physiological stress and child behavior at 18 months of corrected age for infants born preterm. Follow-up of a multicenter, prospective cluster-randomized controlled trial comparing FICare and standard care of children born at <33 weeks of gestation and parents, stratified by tertiary neonatal intensive care units, across Canada. Primary outcomes at 18 months of corrected age were maternal stress hormones (cortisol, ie, hair cumulative cortisol [HCC], dehydroepiandrosterone [DHEA]) assayed from hair samples. Secondary outcomes included maternal reports of parenting stress, child behaviors (Internalizing, Externalizing, Dysregulation), and observer-rated caregiving behaviors. Outcomes were analyzed using multilevel modeling. We included 126 mother–child dyads from 12 sites (6 FICare sites, n = 83; 6 standard care sites, n = 43). FICare intervention significantly lowered maternal physiological stress as indicated by HCC (B = −0.22 [–0.41, −0.04]) and cortisol/DHEA ratio (B = −0.25 [–0.48, −0.02]), but not DHEA (B = 0.01 [–0.11, 0.14]). Enrollment in FICare led to lower child Internalizing (B = −0.93 [–2.33, 0.02]) and Externalizing behavior T scores (B = −0.91 [–2.25, −0.01]) via improvements to maternal HCC (mediation). FICare buffered the negative effects of high maternal HCC on child Dysregulation T scores (B = −11.40 [–23.01, 0.21]; moderation). For mothers reporting high parenting stress at 18 months, FICare was related to lower Dysregulation T scores via maternal HCC; moderated mediation = −0.17 (−0.41, −0.01). FICare has long-term beneficial effects for mother and child, attenuating maternal chronic physiological stress, and improving child behavior in toddlerhood. NCT01852695.