Sleep deprivation and its association with diseases- a review

Sleep deprivation, a consequence of multiple health problems or a cause of many major health risks, is a significant public health concern in this era. In the recent years, numerous reports have been added to the literature to provide explanation and to answer previously unanswered questions on this...

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Bibliographic Details
Published inSleep medicine Vol. 77; pp. 192 - 204
Main Authors Liew, Siaw Cheok, Aung, Thidar
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2021
Subjects
Chronic illness
Diseases
Sleep
Sleep deprivation
Chronic illness
Sleep
Sleep deprivation
Diseases
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Summary:Sleep deprivation, a consequence of multiple health problems or a cause of many major health risks, is a significant public health concern in this era. In the recent years, numerous reports have been added to the literature to provide explanation and to answer previously unanswered questions on this important topic but comprehensive updates and reviews in this aspect remain scarce. The present study identified 135 papers that investigated the association between sleep deprivation and health risks, including cardiovascular, respiratory, neurological, gastrointestinal, immunology, dermatology, endocrine, and reproductive health. In this review, we aimed to provide insight into the association between sleep deprivation and the development of diseases. We reviewed the latest updates available in the literature and particular attention was paid to reports that detailed all possible causal relationships involving both extrinsic and intrinsic factors that may be relevant to this topic. Various mechanisms by which sleep deprivation may affect health were presented and discussed, and this review hopes to serve as a platform for ideas generation for future research. •Chronic sleep deprivation of less than 7 h daily is associated with multiple health disorders.•Sleep deprivation in late pregnancy induces hypertension in offspring.•Sleep deprivation induces neutrophilic inflammation in asthma.•The effects of sleep deprivation encompass the disruptions in immunological interplay and genetic modifications.•Melatonin is postulated as a treatment option to counteract metabolic deficiencies in children with sleep deprivation.
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ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2020.07.048