Evaluation of different ranges of LH:FSH ratios in polycystic ovarian syndrome (PCOS) – Clinical based case control study

• Published in: General and comparative endocrinology Vol. 260; pp. 51 - 57
• Main Authors: Malini, N.A., Roy George, K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2018
• Subjects: Hyperinsulinemia; Infertility; Insulin resistance; Testosterone; Hyperinsulinemia; Testosterone; Insulin resistance; Infertility
• ISSN: 0016-6480; 1095-6840
• DOI: 10.1016/j.ygcen.2017.12.007

•This article is based on mainly polycystic cases with different ranges of LH:FSH Ratios.•It focuses on whether the changes in the level of insulin and testosterone are dependent on changes in LH:FSH Ratios or not.•This study provides the advancement of PCOS from basic level to more complex level in view of various LH: FSH Ratios. Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine and metabolic disorder among reproductive aged women, leading to infertility. One of the common clinical manifestations in PCOS is that there is a difference in the range of LH production in different case of PCOS and accordingly variability in LH:FSH ratio was observed. The aim of the present study was to evaluate different ranges of LH:FSH ratios in PCOS. In this cross sectional study, a consecutive series of 745 women (aged 28.11 ± 0.2) who were subjected to infertility treatment at specialist infertility clinics in central Travancore region were considered. About 50 healthy females (aged 27.58 ± 0.4) with regular menstrual cycles were regarded as control. The data were collected from hospital records using subject’s written informed consent. PCOS patients were observed to have different ranges of LH:FSH ratios from < 1 range to 4.6–5.5 and subjects were classified into 7 PCO subgroups on the basis of their LH:FSH ratios. In whole PCO group, body weight, LH, FSH, LH:FSH ratio, insulin, HbA1c, estradiol, testosterone and TSH were significantly (P < .05) increased whereas progesterone and SHBG levels were significantly (P < .05) decreased in comparison to control. In various PCO subgroups as LH levels and LH:FSH ratios were increased, levels of insulin, testosterone and AMH were increased and SHBG levels were decreased accordingly. This finding suggested a dependence of insulin, LH and testosterone in initiating the hormonal imbalances in PCOS.