Immunological evaluation of a streptococcal preparation (OK-432) in treatment of bladder carcinoma

When 21 patients with bladder cancer (transitional cell carcinoma) were given local and systemic injections of a streptococcal preparation, OK-432, tumor regression was observed in 3 cases (14.3%). The marked infiltration of lymphocytes observed on histological examination of regressed tumors sugges...

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Bibliographic Details
Published inThe Journal of urology Vol. 122; no. 4; p. 467
Main Authors Kagawa, S, Ogura, K, Kurokawa, K, Uyama, K
Format Journal Article
LanguageEnglish
Published United States 01.10.1979
Subjects
Biological Products - therapeutic use
Carcinoma, Transitional Cell - immunology
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - therapy
Female
Humans
Male
Middle Aged
Picibanil - therapeutic use
Urinary Bladder Neoplasms - immunology
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - therapy
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Summary:When 21 patients with bladder cancer (transitional cell carcinoma) were given local and systemic injections of a streptococcal preparation, OK-432, tumor regression was observed in 3 cases (14.3%). The marked infiltration of lymphocytes observed on histological examination of regressed tumors suggested that a host-mediated action was involved in the antitumor effect of OK-432.
ISSN:0022-5347
DOI:10.1016/S0022-5347(17)56466-6