Pediatric Antibiotic Prescribing in China According to the 2019 World Health Organization Access, Watch, and Reserve (AWaRe) Antibiotic Categories

• Published in: The Journal of pediatrics Vol. 220; pp. 125 - 131.e5
• Main Authors: Wang, Chu-ning, Huttner, Benedikt D., Magrini, Nicola, Cheng, Yibing, Tong, Jianning, Li, Shuangjie, Wan, Chaomin, Zhu, Qingxiong, Zhao, Shiyong, Zhuo, Zhiqiang, Lin, Daojiong, Yi, Bin, Shan, Qingwen, Long, Mei, Jia, Chunmei, Zhao, Dongchi, Sun, Xiaofeng, Liu, Juan, Zhou, Yibo, Li, Rui, Liu, Jing, Zhu, Yu, Miao, Ruixue, Zhu, Chunhui, Qi, Zhenghong, Wang, Caihong, Wu, Shouye, Xu, Xiaohong, Zhou, Li, Ye, Wenyu, Luo, Na, Gao, Huiling, Yang, Pu, Bieerding, Maihebuba, Tang, Jie, Zeng, Mei, Xia, Jialing, Yan, Huiqun, Liu, Tao, Su, Zhixiong, Liang, Xiaochun, Chen, Jian, Wang, Daobin, Zhao, Yun, Zhang, Liling, Gu, Shen-feng, Zhu, Jun, Lan, Chenfu, Hu, Hui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2020
• Subjects: Adolescent; Anti-Bacterial Agents - classification; Anti-Bacterial Agents - therapeutic use; Child; Child, Preschool; China; Cross-Sectional Studies; Drug Prescriptions - statistics & numerical data; Drug Utilization - statistics & numerical data; Humans; Infant; Practice Patterns, Physicians; Prospective Studies; World Health Organization; China; ATC; AWaRe; URTI; WHO
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2020.01.044

To assess clinical indication-specific antibiotic prescribing in pediatric practice in China based on the World Health Organization (WHO) Access, Watch, and Reserve (AWaRe) metrics and to detect potential problem areas. Pediatric prescription records on the 16th of each month during 2018 were sampled for all encounters at outpatient and emergency departments of 16 tertiary care hospitals via hospital information systems. Antibiotic prescribing patterns were analyzed across and within diagnostic conditions according to WHO AWaRe metrics and Anatomical Therapeutic Chemical (ATC) classification. A total of 260 001 pediatric encounters were assessed, and antibiotics were prescribed in 94 453 (36.3%). In 35 167 encounters (37.2%), at least 1 intravenous antibiotic was administered. WHO Watch group antibiotics accounted for 82.2% (n = 84 176) of all antibiotic therapies. Azithromycin (n = 15 791; 15.4%) was the most commonly prescribed antibiotic, and third-generation cephalosporins (n = 44 387; 43.3%) were the most commonly prescribed antibiotic class. In at least 66 098 encounters (70.0%), antibiotics were prescribed for respiratory tract conditions, mainly for bronchitis/bronchiolitis (n = 25 815; 27.3%), upper respiratory tract infection (n = 25 184; 26.7%), and pneumonia (n = 13 392; 14.2%). Overuse and misuse of WHO Watch group antibiotics for respiratory tract conditions and viral infectious diseases is common in pediatric outpatients in China. Pediatric antimicrobial stewardship should be strengthened using WHO AWaRe metrics.