Carbapenem-resistant Enterobacteriaceae: An emerging bacterial threat

The first reports of carbapenem resistance in Enterobacteriaceae isolates occurred in the early 1990s. Researchers published the first report of an isolate that produced Klebsiella pneumoniae carbapenemase in 2001. Since that time, carbapenemase-producing Enterobacteriaceae isolates have disseminate...

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Bibliographic Details
Published inSeminars in diagnostic pathology Vol. 36; no. 3; pp. 182 - 186
Main Author Lutgring, Joseph D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2019
Subjects
Antibiotic
Bacterial Proteins - metabolism
beta-Lactamases - metabolism
Carbapenem
Carbapenem-Resistant Enterobacteriaceae - drug effects
Carbapenems - pharmacology
Communicable Diseases, Emerging - epidemiology
Communicable Diseases, Emerging - microbiology
CRE
Drug Resistance, Bacterial
Enterobacteriaceae
Enterobacteriaceae Infections - epidemiology
Enterobacteriaceae Infections - microbiology
Humans
Phenotype
Resistance
Resistance
Carbapenem
Antibiotic
CRE
Enterobacteriaceae
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Summary:The first reports of carbapenem resistance in Enterobacteriaceae isolates occurred in the early 1990s. Researchers published the first report of an isolate that produced Klebsiella pneumoniae carbapenemase in 2001. Since that time, carbapenemase-producing Enterobacteriaceae isolates have disseminated globally. Microbiology laboratories are integral to the control of carbapenem-resistant Enterobacteriaceae (CRE). Laboratories need to be able to identify CRE, identify possible therapeutic alternatives, and sometimes identify the type of mechanism responsible for the carbapenem-resistant phenotype. Knowledge of these tasks is essential for all clinical microbiology laboratorians.
Bibliography:ObjectType-Article-2
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ISSN:0740-2570
1930-1111
DOI:10.1053/j.semdp.2019.04.011