Relation of selenium status to neuro-regeneration after traumatic spinal cord injury

• Published in: Journal of trace elements in medicine and biology Vol. 51; pp. 141 - 149
• Main Authors: Heller, Raban Arved, Seelig, Julian, Bock, Tobias, Haubruck, Patrick, Grützner, Paul Alfred, Schomburg, Lutz, Moghaddam, Arash, Biglari, Bahram
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.01.2019
• Subjects: Adolescent; Adult; Aged; Biomarker; Brain; ELISA; Female; Humans; Inflammation; Injury; Male; Middle Aged; Neurodegeneration; Neuron; Paraplegia; Precision medicine; Prediction; Profile; Recovery; Selenium - blood; Selenoprotein P; Selenoproteins - blood; Spinal Cord Injuries - blood; Spinal Cord Injuries - epidemiology; Spinal Cord Regeneration; Supplementation; Surgery; Trace element; Young Adult; Zinc; Brain; Biomarker; Injury; Prediction; Inflammation; Recovery; Zinc; Profile; Trace element; Paraplegia; Neuron; Precision medicine; Neurodegeneration; Surgery; Supplementation; Selenoprotein P; ELISA
• ISSN: 0946-672X; 1878-3252; 1878-3252
• DOI: 10.1016/j.jtemb.2018.10.006

The trace element selenium (Se) is crucial for the biosynthesis of selenoproteins. Both neurodevelopment and the survival of neurons that are subject to stress depend on a regular selenoprotein biosynthesis and sufficient Se supply by selenoprotein P (SELENOP). Neuro-regeneration after traumatic spinal cord injury (TSCI) is related to the Se status. Single-centre prospective observational study. Three groups of patients with comparable injuries were studied; vertebral fractures without neurological impairment (n = 10, group C), patients with TSCI showing no remission (n = 9, group G0), and patients with remission developing positive abbreviated injury score (AIS) conversion within 3 months (n = 10, group G1). Serum samples were available from different time points (upon admission, and after 4, 9 and 12 h, 1 and 3 days, 1 and 2 weeks, and 1, 2 and 3 months). Serum trace element concentrations were determined by total reflection X-ray fluorescence, SELENOP by ELISA, and further parameters by laboratory routine. Serum Se and SELENOP concentrations were higher on admission in the remission group (G1) as compared to G0. During the first week, both parameters remained constant in C and G0, whereas they declined significantly in the remission group. Similarly, the concentration changes between admission and 24 h were most pronounced in this group of recovering patients (G1). Binary logistic regression analysis including the delta of Se and SELENOP within the first 24 h indicated an AUC of 90.0% (CI: 67.4%–100.0%) with regards to predicting the outcome after TSCI. A Se deficit might constitute a risk factor for poor outcome after TSCI. A dynamic decline of serum Se and SELENOP concentrations after admission may reflect ongoing repair processes that are associated with higher odds for a positive clinical outcome.