Immunoglobulin E-Mediated Severe Allergy to Human Seminal Plasma

Two women with allergy to human seminal plasma are described. Both patients had generalized and local allergic symptoms, i.e., hypotension, asthmatic dyspnea, urticaria, and vaginal swelling, beginning within a few minutes of intercourse. The antigen causing the reaction in these patients was common...

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Published inFertility and sterility Vol. 28; no. 8; pp. 832 - 835
Main Authors Reunala, Timo, Koskimies, Aarne I., Björksten, Fred, Jänne, Juhani, Lassus, Allan
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.1977
Subjects
Adult
Antigens - analysis
Female
Humans
Hypersensitivity - etiology
Hypersensitivity - immunology
Immunization, Passive
Immunoglobulin E - analysis
Infant, Newborn
Male
Pregnancy
Semen - immunology
Skin Tests
Urticaria - immunology
Vaginitis - immunology
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Summary:Two women with allergy to human seminal plasma are described. Both patients had generalized and local allergic symptoms, i.e., hypotension, asthmatic dyspnea, urticaria, and vaginal swelling, beginning within a few minutes of intercourse. The antigen causing the reaction in these patients was common to all seminal plasmas examined. Most of the antigenic activity was shown to be present in one protein band detected by acrylamide gel electrophoresis. The seminal plasma reaction was mediated through an immunoglobulin E (IgE) antibody. Passive transfer of the hypersensitivity with the serum of both patients was successful, and the radioallergosorbent test showed that the serum of the first patient contained IgE specific to seminal plasma.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ISSN:0015-0282
1556-5653
DOI:10.1016/S0015-0282(16)42736-6