Cystinuria: Effect of D-Penicillamine on Plasma and Urinary Cystine Concentrations

Administration of penicillamine reduced the concentration of cystine in the plasma and urine of patients with cystinuria; renal clearance of cystine, lysine, and arginine remained unchanged. Cysteine-penicillamine disulfide and penicillamine disulfide were detected in the plasma.

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 147; no. 3664; pp. 1459 - 1460
Main Authors Crawhall, J. C., Thompson, C. J.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 19.03.1965
Subjects
Amino acids
Arginine
Blood
Cyanobacteria
Cysteine
Cystine
Cystinuria
Disulfides
Drug Therapy
Excretion
Humans
Lysine
Old Medline
Optical density
Penicillamine
Pseudomonas
Quaternary ammonium compounds
Renal clearance
Sulfides
Urine
CYSTINURIA
SULFIDES
DRUG THERAPY
LYSINE
URINE
ARGININE
PENICILLAMINE
BLOOD
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Summary:Administration of penicillamine reduced the concentration of cystine in the plasma and urine of patients with cystinuria; renal clearance of cystine, lysine, and arginine remained unchanged. Cysteine-penicillamine disulfide and penicillamine disulfide were detected in the plasma.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.147.3664.1459