Utility of Bruch membrane opening-based optic nerve head parameters in myopic subjects

• Published in: European journal of ophthalmology Vol. 28; no. 1; p. 42
• Main Authors: Sastre-Ibañez, Marina, Martinez-de-la-Casa, Jose M, Rebolleda, Gema, Cifuentes-Canorea, Pilar, Nieves-Moreno, Maria, Morales-Fernandez, Laura, Saenz-Frances, Federico, Garcia-Feijoo, Julian
• Format: Journal Article
• Language: English
• Published: United States 01.01.2018
• Subjects: Adolescent; Adult; Bruch Membrane; Cross-Sectional Studies; Female; Humans; Image Interpretation, Computer-Assisted - methods; Male; Middle Aged; Myopia - pathology; Nerve Fibers - pathology; Optic Disk - pathology; Prospective Studies; Retinal Ganglion Cells - pathology; Software; Tomography, Optical Coherence - methods; Young Adult; Optic nerve head; Bruch membrane opening; Retinal nerve fiber layer; Optical coherence tomography; Myopia
• ISSN: 1724-6016
• DOI: 10.5301/ejo.5001022

To evaluate whether the new rim analysis software with spectral-domain optical coherence tomography (SD-OCT) shows advantages over the retinal nerve fiber layer (RNFL) thickness in patients with moderate myopia. In this prospective cross-sectional study, we studied 65 healthy subjects, 37 with spherical refractive errors in the range of -3 to -6 D (moderate, G1) and 28 with less than -3 D (low/non-myopic, G0). All patients were examined with Heidelberg Spectralis SD-OCT, including Glaucoma Premium Module Edition (GPME) software. With GPME, we analyzed the neuroretinal rim (Bruch membrane opening-minimum rim width [BMO-MRW]) and RNFL. The average age of subjects was 30.2 ± 9.3 years for G0 and 29.9 ± 7.1 years for G1 (p = 0.903). Mean sphere was -0.5 ± 0.3 D (-1.25 to 0 D) G0 and -3.9 ± 0.3 D (-6.00 to -3 D) G1 (p<0.001). The RNFL thickness comparison between G0 and G1 showed a significantly lower thickness in G1 (p = 0.018). The BMO-MRW measurements were similar in both groups (p = 0.331). With the BMO-MRW examination, the number of sectors classified as pathologic per subject in G1 were significantly lower compared to RNFL analysis (p = 0.023). Ring analysis based on BMO-MRW measurements shows a lower rate of false-positives compared to RNFL thickness when studying healthy moderate myopic eyes and it would be advisable to take this into consideration when analyzing these patients.